The Norway-born Ghana goalkeeper who is set to earn his first call up for Ghana will test his shot stopping skills against Atletico's crop of world renowned strike force of Diego Forlan and Segio Aguerro.
He says the game is massive for his career and is keen to prove himself worthy while helping his club side through to the next round of the competition.
Kwarasey and his teammates will travel to Madrid for the first leg on July 8 before playing host in the return leg on August 4.