Manchester United were eliminated from the FA Cup after a 4-3 defeat on penalties to Fulham on Sunday evening.
Christian Eriksen and Noussair Mazraoui were restored to the eleven for United that started the win over Ipswich Town.
Ruben Amorim's men cautioned the visitors in the earlier exchanges with Bruno Fernandes launching from the edge of the box, but goalkeeper Bernd Leno draw a save.
Leno needed to come to his side's aid once again when he pushed to his near side to guide a curler from Fernandes into touch.
The Red Devils quest to going ahead were undone on the stroke of halftime as Calvin Bassey nodded a cutback from a corner-kick in the bottom-corner and out of Andre Onana's reach.
A double substitution for United moments in the second period saw Alejandro Garnacho come on for Manuel Ugarte before Victor Lindelof entered in place of Levy Yoro.
Fernandes remained the go-to-guy man for the host and lined-up a speculative shot that put the opposite number Leno in some bother.
The former Sporting man proved decisive with 20 minutes to play when he combined with Diogo Dalot and rifled in the bottom-corner.
Fulham nearly restored the lead towards the end with a snap shot on the edge of the area by Emile Smith Rowe, but Onana dived down and palmed into touch.
Amorim's men went close themselves in the lengthy period of stoppage time through substitute Chindo Obi-Martin going across the face of goal having opened up space.
The winner didn't materialise in regulation time and steered the contest to a period of extra-time to determine a victor.
Not too much openings from either side in the additional spell showed though Ryan Sessegnon got close with a curler from a tight angle, but Onana palmed.
Fulham snatched victory in the penalty shoot-out after it remained level in regulation time, as Leno made two saves including the decisive one of Joshua Zirkzee to see them through.