Al Ahly got their first win in Group B after sinking Al-Hilal Omdurman 2-1 at Cairo International Stadium.
Hussein El Shahat and Ramadan Sobhi scored in each half for the Egyptian giants.
Althar El Tahir pulled a goal back for the Sudanese outfit deep in stoppage time, but it was too late to deny Al Ahly the three points.
Esperance Tunis maintained their winning start in Group D after edging JS Kabylie 1-0 at Stade Olympique de Rades.
After a score-less first stanza, Anice Badri finally found the breakthrough for Esperance in the 73rd minute from the penalty spot.
The Tunisian giants went to the top of the pool with a maximum of six points, while the Algerian side had to settle for second spot with three points.
Raja Casablanca clinched their first win in Group D after edging AS Vita Club 1-0 at Stade des Martyrs de la Pentecote in Kinshasa.
Soufiane Rahimi broke the deadlock for Raja three minutes after the break, which proved to be the winner.
Vita lost their second straight match in the pool and are rooted at the bottom, while Raja moved up to third.