Lallana has not featured for the Reds this term after suffering a thigh injury in a pre-season friendly against Atletico Madrid but looks set to face Southampton at Anfield on Saturday.
Meanwhile, Merseyside skipper Henderson has been out with the same injury but is back training at Melwood, although the England midfielder is set to miss the visit of the Saints.
Further injury updates at Anfield have seen Philippe Coutinho already recovered from an adductor injury, although fellow forward Sadio Mane is not expected to be risked after returning from duty with Senegal with a recurrence of his hamstring strain.
Meanwhile, Reds coach Jurgen Klopp's involvement in this weekend's Premier League clash is also in doubt after the German admitted himself to hospital on Wednesday evening after feeling ill.