Following the dismissal of Dani Alves against Atletico Madrid before the FIFA break, the Catalans went for a single switch in Sergino Dest from that high-tempo encounter at Camp Nou.
Barcelona made an electrifying start straight from the start when Pedri popped up at the far side of the area to tuck in Jordi Alba's cross-field ball from the left of the area.
As the dominant spell continued, Barca failed to add on to their lead minutes apart as Ferran Torres nodded a floating ball into the centre of the area from Alba over the top.
The host equalised five minutes before halftime after Sergi Darder collected a cutback wide of the area from Raul de Thomas and curled into the far corner amidst an outstretched Ter Stegen.
Barca made a substitution following the restart in Eric Garcia for Ronald Araujo, and appeared to have regained the lead on 55 minutes through Gavi's smart finish but it was disallowed for offside.
For the Periquitos, the match began to even out and to that they went ahead midway in the second half after De Thomas brought down a ball over the top to apply a composed close-range finish.
An approach to turn the tie around from the Catalans followed minutes later from a penetrative delivery to the area by Alba, but Torres headed across the face of goal after a giant leap.
There were no shortage of drama in added time, as a scuffle between Gerard Pique and Nico Melamed ended with both players being dismissed after receiving their second yellows.
Barca weren't affected and levelled when Luuk de Jong stayed ahead of the defence to head in Adama Traore's cross and left the clash level in the final minute of regulation time.