Reigning DStv Premiership champions Mamelodi Sundowns were drawn against Angolan side Petro de Luanda in the CAF Champions League quarter-final draw in Cairo on Tuesday.
Masandawana reached the knockout stage of the competition after recording a tournament-record 16 points from their group, ahead of reigning champions Al Ahly, who have been drawn against Raja Casablanca.
Quarter-final 1: Al Ahly (Egypt) v Raja Casablanca (Morocco)
Quarter-final 2: ES Setif (Algeria) v ES Tunis (Tunisia)
Quarter-final 3: CR Belouizdad (Algeria) v Wydad AC (Morocco)
Quarter-final 4: Petro de Luanda (Angola) v Mamelodi Sundowns (South Africa)
In the CAF Confederation Cup, Soweto giants and 2015 runners-up Orlando Pirates will meet Tanzania's Simba SC in the quarter-final of the competition.
The Buccaneers progressed to the next round of the prestigious tournament after topping the Group B standings with four wins and one draw from their six matches, ahead of Libyan giants Al-Ittihad.
Quarter-final 1: Simba SC (Tanzania) v Orlando Pirates (South Africa)
Quarter-final 2: Al-Ittihad (Libya) v Al Ahly Tripoli (Libya)
Quarter-final 3: Pyramids FC (Egypt) v TP Mazembe (DR Congo)
Quarter-final 4: Al Masry (Egypt) v RS Berkane (Morocco)
The winner of quarter-final two will host the winner from quarter-final one in the semi-finals, while the winner of quarter-final four will meet the victor from quarter-final three.