Goals from Thabo Rakhale and Menzi Masuku on either side of half-time ensured Bucs take the full three points on offer, to maintain second spot in Group B.
A 37th minute Thabo Rakhale strike broke the deadlock after great link-up play from a throw-in saw Erasmus find Manyisa in space, who teed it up nicely for Rakhale to bang into the top right-hand corner of the Sfaxien goal.
The Bucs went into the tunnel the happier of the two sides as they took a 1-0 lead at the half-time break.
Menzi Masuku doubled the home side's lead in the 54th minute after a searching clearance from Patrick Phungwayo found Erasmus in space, who then played in Masuku, who coolly finished off the move.
Mhlongo; Phungwayo, Sangweni, Jele, Nyauza; Myeni, Sarr, Manyisa (Ntshumayelo 85'), Rakhale; Masuku, Erasmus (Majoro 64').
Subs: Ovono, Mahamutsa, Masalesa, Ntshumayelo, Makola, Memela, Majoro.
Rami; Ali, B. Selim, Zied, Wajdi; Dali, Yasine, Hamza, Maher; M. Selim, Borhen.