The Buccaneers are leading 2-0 from the first leg, and will be confident of getting the job done at Bidvest Stadium.
Siyabonga Sangweni and Mpho Makola are suspended, meaning a recall for Rooi Mahamutsa and Thabo Rakhale.
There is also a change up-front, where Kermit Erasmus starts ahead of Lehlohonolo Majoro.
Orlando Pirates: Mhlongo - Jele, Mahamutsa, Nyauza, Matlaba - Rakhale, Manyisa, Sarr, Myeni - Erasmus, Gabuza. Subs: Zikalala, Gcaba, Ntshumayelo, Masalesa, Qalinge, Bacela, Majoro
AS Khaloum: Toure, Bangoura, Banh, Camara, Camara, Konte, Kouyate, Sylla, Diawara, Kassongo, Camara. Subs: Camara, Badji, Sylla, Soumah, Sow, Balo, Thiam