Bucs - who beat AC Leopards 2-0 on the weekend - and Zamalek have 12 points apiece from five games.
Both teams are already through to the semi-finals of the competition, as are joint-Group A leaders Al Ahly and ES Sahel (10 points each).
Ahly edged Esperance 1-0 on Saturday, while Sahel drew 1-1 with Stade Malien on Sunday.
Pirates will meet Zamalek in Cairo on September 12, having lost 2-1 to the White Knights at Mbombela Stadium on July 11.