The aristocratic club, known as the White Knights, need just one point from their last two games of the season to quench a long-standing drought and add back a competitive edge to their bitter rivalry with Al Ahly, who won a record 37th championship at the end of last season.
A draw away at Al Geish, behind closed doors at Cairo’s Air Defence Stadium, will give Zamalek their first league success since 2004.
Zamalek, coached by the Portuguese Jesualdo Ferreira, could have sewn up the title last week but lost their derby to Al Ahly, who have won eight titles in the last decade with two seasons not completed because of the civil interest in the country.
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This year’s championship has run over after being suspended for just over a month after 22 people were killed in a stampede on February 8 when police fired teargas and birdshot at Zamalek supporters trying to force their way into the Air Defence Stadium.
Football matches have often been a flashpoint for violence in Egypt where 72 Al Ahly fans were killed in Port Said in February 2012, prompting a halt to club football for almost a year.