Third-placed Uthongathi, just a point behind second-placed Swallows, are due to meet at Dobsonville Stadium on Saturday but will now be without their head coach.
The Cane Cutters led the NFD early on in the season but a sequence of just one win in their last eight league matches as well as a Nedbank Cup exit against Highlands Park has led to the departure of the coach.
The club released a statement on Wednesday stating that the club decided to release Ferreira due to unfortunate results.
"Uthongathi Football Club wishes to announce that we have parted ways with John George Ferreira," read the statement.
"We have worked with Mr Ferreira for two seasons. He is a marvelous coach parked with experience. He lives and dreams football but unfortunately the results weren't coming."
The club confirmed that assistant coach Sifiso Dladla will take over the reins alongside Goalkeeper coach Olivier Kouadio for the remainder of the season.