Absa Premiership leaders Mamelodi Sundowns have it comparatively easy against lower league side EC Bees FC in the next round of the competition, as do Baroka with their match-up against Steenberg United.
Last season's champions, SuperSport United were dumped out of the event after losing on penalties to Bloemfontein Celtic, who next face Richards Bay.
Free State Stars and Chippa United will collide in all-topflight affair.
Maritzburg United will make the trip to NFD strugglers Royal Eagles.
Ubuntu Cape Town will have another chance at a giant-killing as they travel to Durban to take on AmaZulu.
Kaizer Chiefs v Stellenbosch
Cape Town City v Orlando Pirates
Royal Eagles v Maritzburg United
AmaZulu v Ubuntu Cape Town
Free State Stars v Chippa United
Mamelodi Sundowns v EC Bees FC
Bloemfontein Celtic v Richards Bay
Baroka v Steenberg United