The most affected club is Cape Town City, who will be without two players and their goalkeeper coach for their visit to Bidvest Wits on Wednesday evening.
The central defensive partnership between skipper Robyn Johannes and Taariq Fielies has been dismantled after both players were booked in their heated league outing against Mamelodi Sundowns last Friday.
Goalkeeper coach Brian van der Heever will also be missing after being given his marching orders by referee Victor Gomes in the said match, and will miss the club's next two outings.
A welcome boost for The Citizens, however, will be head coach Benni McCarthy's return to the bench after serving his two-match suspension.
AmaZulu, who take on National First Division side Mthatha Bucks at King Zwelithini Stadium on Wednesday, will be without midfield anchorman Michael Morton, while the visitors will have to replace skipper Thabiso Mokoena.
The evening's other fixture between Ubuntu Cape Town and Polokwane City at the Athlone Stadium is without suspensions.