Banyana coach Desiree Ellis did ring the changes after the 3-0 defeat to the Brazilians three days ago, with goalkeeper Kaylin Swart, Janine van Wyk, Asanda Hadebe and Mapula Nomvula all recalled.
The South Americans picked up from where they left off in Friday's win, with Adriana getting the opening goal five minutes after the kick-off for her second goal in as many games.
Swart kept Banyana in the contest after 20 minutes as she was able to keep out Ary Borges' strike in a one-on-one situation, before the shot-stopper swarted Debinha's effort after a poor pass out from the back.
Debinha and the South Americans would get their reward in first-half stoppage time to head into the halftime break with a two-goal lead, while Banyana barely threatened the visitors' goal.
The South Americans were awarded a penalty minutes after the break when Swart brought down Bia Zaneratto, who calmly slotted the spot-kick into the far corner.
Brazil showed no signs of slowing down as the added a fourth goal on 50 minutes when Duda added her name to the scoresheet with a simple finish after the visitors broke Banyana's high defensive line.
Defender Kathellen got in on the act after 58 minutes with a close-range header after Beatriz won here initial header from a set-piece situation.
After more waves of attack, Brazil did add a sixth goal with eight minutes left on the clock when Debinha rose high to head home a cross from Kerolin to wrap up a big win.