Chelsea were handed their first loss in the Premier League following a 3-1 defeat to ten-man West Ham United on Sunday evening.
New signing Moses Caicedo was named on the bench by the Blues, who were without club captain Reece James due to a long-term injury as Malo Gusto made his full debut for the club at right-back.
It was a disappointing opening for the Blues as the Hammers went ahead on nine minutes when Nayef Aguerd towered high in the area to head in a pin-point corner from James Ward-Prowse.
Chelsea were fortunate not to get a spot-kick from a foul on Nicolas Jackson by goalkeeper Alphonse Areola, but nothing came thereof with the player caught offside by the pitch-side review team.
The Blues' persistent spell of pressure paid off before the half-hour mark as youngster Carney Chukwuemeka showed smart foot-work in the area and curled into the top corner.
However, Chelsea could've gone ahead on 41 minutes through a spot-kick by Enzo Fernandez following a foul on Raheem Sterling but Areola smothered the Argentine international.
Chelsea coach Mauricio Pochettino made a change following the resumption when Chukwuemeka picked up a knock and made way for Ukraine international Mykhailo Mudryk.
David Moyes' men were in front again a little to five minutes after halftime when Michail Antonio displayed great body strength around the area and nestled a powerful strike into the bottom-corner.
As Caicedo entered for his debut when he replaced Ben Chilwell, the Hammers went a man down towards the last 20 minutes when Aguerd was shown a red card for a rash tackle on Jackson.
With action either end in additional time, Reported Manchester City target Lucas Paqueta sealed the win by sending Blues goalkeeper Robert Sanchez the wrong way from the penalty spot after Caicedo committed a foul in the area.
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