Manchester City cruised to the fourth round after beating Championship side Birmingham City 3-0 courtesy of a brace by Bernardo Silva at the Etihad Stadium.
Man City made five changes, with Kyle Walker, Benjamin Mendy, Rodrigo, Bernardo Silva and Gabriel Jesus all recalled to boost the side that was recently hit by a coronavirus outbreak.
Silva grabbed a brace for Man City in the first quarter of an hour while Phil Foden got the the third goal eight minutes before the break.
Riyad Mahrez thought he had made it 4-0 for Pep Guardiola's charges on the hour-mark but his goal was disallowed for offside by the Video Assistant Referee (VAR).
Chelsea booked their spot in the fourth round after hammering League Two side Morecambe 4-0 at Stamford Bridge.
The Blues manager Frank Lampard shuffled the pack, with goalkeeper Kepa, Antonio Ridiger, Emerson, Billy Gilmour, Kai Havertz and Callum Hudson-Odoi all given a run in the line-up.
Mason Mount and Timo Werner gave the hosts a two-goal lead going to the break, Hudson-Odoi got the third goal early in the second stanza and Havertz sealed a thumping win with the fourth goal in the last five minutes.
Leeds United crashed out in the third round after a shock 3-0 defeat to fourth tier side Crawley Town at The People's Pension Stadium.
Leeds made wholesale changes, with only Rodrigo, Ezgjan Alioski, Pascal Struijk and Kalvin Phillips remaining in the line-up from their 3-0 defeat against Tottenham Hotspur.
After a scoreless first stanza, Nick Tsaroulla broke the deadlock for the home side five minutes inside the second stanza while Ashley Nadesan doubled their lead three minutes later and Jordan Tunnicliffe secured Crawley's passage into the fourth round with the third goal in the last 20 minutes.