Tottenham Hotspur's only hope for silverware this season is the UEFA Champions League after a penalty shoot-out loss to Norwich City in the Emirates FA Cup on Wednesday evening.
Jan Vertonghen's first-half opener looked to set the Lily Whites on their way, however Josip Drmic forced the match into extra-time late in the second half.
The two sides couldn't be separate following the additional times and a penalty shoot-out followed, which the Canaries won after Tim Krul saved two penalties.
Manchester City put on a gutsy performance to scrape out a 1-0 win over Championship side Sheffield Wednesday at Hillsborough.
City, who just clinched the Carabao Cup over the weekend, give a run to a few fringe players such as Claudio Bravo in goal and Joao Cancelo at right back.
However, after a goalless first half Sergio Aguero broke the deadlock in the second half to put the Citizens in the last eight.
Leicester City booked their quarter-final spot with a 1-0 win over Birmingham City at the King Power Stadium.
Leicester, who had battled for form of late following two successive defeats, struggled for large parts as the Championship side proved too stubborn to crack.
Ricardo Pereira finally broke their resistance in the 82nd minute to keep their chances of grabbing silverware this alive
Sheffield Utd vs Arsenal
Newcastle United v Manchester City
Norwich City v Derby County or Man Utd
Leicester City v Chelsea