Ivory Coast won't be participating in the 2022 FIFA World Cup after a 1-0 loss to Cameroon in a Group D qualifier on Tuesday saw them miss out on the play-off stages.
Karl Toko Ekambi grabbed the only strike of the match in the first half, which secured the victory and top spot in the group while the Elephants miss out a fourth straight World Cup appearance.
Tunisia cruised into the World Cup play-offs with a 3-1 victory over Zambia to also win Group B at the Stade Olympique de Rades.
The Carthage Eagles were smarting from a shock defeat at Equatorial Guinea on Saturday, but an opener early on from Aissa Laidouni set the tone.
Mohamed Drager and Ali Maaloul followed with strikes before halftime that proved enough, with Fashion Sakala bagging a consolation for Chipolopolo.
With a World Cup playoff ticket confirmed, Morocco signed off their qualification journey in style as a 3-0 win over Guinea ensured that they finish Group I with six wins from six matches.
Following a brace over Sudan on Friday, Ryan Mmaee became the hero again with another double and saw Ayoub El Kaabi complete the visitors plight to leave Guinea in third spot and winless.
Mauritania recovered from their 4-0 drubbing by Zambia to hold the Equatorial Guinea to a 1-1 draw in their final qualifier in Group B.
Overseas-based Aboubakar Kamara granted the host the lead in the middle period of the first half and saw Saul Coco arrive following the second period to level it up.
African champions Algeria made sure of their spot in the 2022 FIFA World Cup play-offs following a 2-2 draw against Burkina Faso in Group A on Tuesday.
The Desert Foxes hit the front early on courtesy of Riyad Mahrez, but it was wiped out by Zakaria Sanogo only to see Sofiane Feghouli restore their lead before Issoufou Dayo's penalty levelled it up.
Burkina entered this match high in confidence as did the Desert Foxes, who will now head the top of the group and leave the Stallions in second spot.
Nigeria qualified for the World Cup play-offs despite playing to a 1-1 draw against the Cape Verde Islands in Group C at the Teslim Balogun Stadium.
The Super Eagles bagged the opening goal in the first minute through Victor Osimhen, which lasted just five minutes after Stopira went and brought the Islanders back on level terms.
However, This particular outcome secured top spot for the Super Eagles, two points ahead of second-place Cape Verde.
Egypt, who qualified over the weekend, defeated Gabon 2-1 in their final Group F clash.
A fourth minute penalty from Mohamed Magdy put Egypt ahead, but Gabon drew a response through Jim Allevinah before an own-goal from Johann Obiang handed the Pharaohs victory, while Gabon's Denis Bouang picked up a red card with minutes to go.
In Group C's other clash, Liberia finished off their qualifying journey with a 3-1 victory the Central African Republic at the Grand Stade de Tanger.
A brace from Peter Wilson added to the second minute opener from Marcus Macauley as Isaac Ngoma brought the visitors a consolation.
Mozambique ended their qualifying campaign in Group D clash with a 1-0 loss to Malawi in Cotonou.
AmaZulu defender Limbikani Mzava's own-goal six minutes in the second half landed the Mambas the victory.
Libya completed their qualifying campaign in Group F with a 1-1 draw against Angola at the 28 March Stadium in Benghazi.
Following a goalless first half, the Libyans launched the first strike through a penalty from Sanad Al Ouarfali before Zini equalised to leave the host third in the group and Angola bottom.