Nigeria were left stunned by the Central African Republic, who struck a late blow to see out a 1-0 win in a Group C 2022 FIFA World Cup qualifier on Thursday.
The Super Eagles still lead the group though, whilst the visitors moved off the bottom following the win which came at the death through Karl Namnganda.
Nigeria will look to avenge this loss in the return encounter on Sunday to in-turn get their World Cup qualifying campaign back on track.
Tunisia's hundred percent start to their qualifying campaign in Group B signalled a 3-0 victory over bottom-dwellers Mauritania.
Ellyes Skhiri and Wahbi Khazri's first half efforts put the Carthage Eagles in control before Seifeddine Jaziri bagged the third within the latter periods.
Benin leaped to the top of Group J ahead of the Democratic Republic of Congo after getting a 1-0 win over Tanzania in Dar-es-Salaam.
French-based and talisman Steve Mounie came forth with the winner in the second half, leaving the Taifa Stars in third place with the second tie happening on Sunday in Cotonou.
The Democratic Republic Congo fired Southern African islanders Madagascar to a third straight loss in the group's other clash following a 2-0 triumph.
Goals either half by Chadrac Akolo and a penalty from Dieumerci Mbokani led the host to victory and second -place adrift Group J's leaders Benin.
Greek-based Garry Rodrigues came to Cape Verde Islands aid with a late finish that secured a 2-1 victory over Liberia in Group C.
Liberia were first on the front-foot courtesy of Van-Dave Harmon ahead of halftime, but Jamiro Monteiro got the Islanders level thereafter with the winner coming from Rodrigues.
Ten-man Zambia came unstuck against Equatorial Guinea as a 2-0 defeat in Malombo left their campaign in Group B firmly in tatters.
For Equatorial Guinea, the win boosted their qualification campaign with Saul Coco and Emilio Nsue on target, whilst Chipolopolo saw Prince Mumba dismissed in the first half.
Uganda finally made a winning start to their qualifying campaign in Group E courtesy of a 1-0 victory over Rwanda away from home.
The Cranes started their campaign with back-to-back draws, as Fahad Bayo's first half strike ensured such does not occur in the city of Kigali.
Mali showed their East African counterparts Kenya no mercy with a 5-0 drubbing at the Stade Adrar to move clear at the top of Group E.
Ibrahima Kone's first half hat-trick handed Mali the perfect platform in addition to Adama Traore's opener whilst Moussa Doumbia added the icing on the cake.