Carlos Queiroz's Egypt took a big leap towards the play-offs after defeating Libya in a 2022 FIFA World Cup qualifier in Benghazi on Monday night.
The Pharaohs, who won the reverse fixture on Friday, opened a four-point gap at the summit of the group on the back of this victory with the Libyans in second spot.
Ahmed Fattoh opened the floodgates followed by Mostafa Mohamed's finish on the stroke of halftime, while Ramadan Sobhi put the icing on the cake late in the contest.
Cameroon claimed back-to-back wins in Group D through a 1-0 victory over Mozambique to keep their ambitions towards top spot alive.
This victory followed Friday's triumph in the reverse fixture, as Michael Ngadeu-Ngadjui's sole strike late in the second half proved enough for the three points.
Ivory Coast, meanwhile, cemented top spot in the aforementioned group's other battle following a 2-1 win at home to Malawi.
Arsenal's Nicolas Pepe handed the Elephants the ideal start after two minutes before Khuda Muyaba brought matters level minutes later.
However, AC Milan midfielder Franck Kessie netted a penalty in the second half to wipe out the Flames chances of a point nor comeback victory.
Angola's qualifying aspirations in Group F suffered a set-back with a 2-0 loss against Gabon.
After a goalless first half, Arsenal forward Pierre-Emerick Aubameyang got the ball rolling before Alex Moucketou-Moussounda made the points safe late on.
Burkina Faso increased their chances to qualify for the final 2022 World Cup play-offs with a 2-0 win over Djibouti, who finished with ten players in a Group A clash.
The Stallions were ahead through Issoufou Dayo's first half opener and made it two in the second half courtesy of Abdoul Tapsoba, whilst Djibouti had Aptidon Saad Daher dismissed.