FC Barcelona failed to strengthen their grip at the top of the table following a disappointing 1-1 draw against Real Betis on Saturday night.
Manager Hansi Flick featured striking duo in the form of Ferran Torres and Robert Lewandowski who were mesmerizing last weekend against Girona.
It took the title-chasing host just seven minutes to seize control when a quick passing move saw Torres release Gavi in-behind to apply a smart finish in the bottom-corner.
Los Verdiblancos were back on level terms not long thereafter as good work from loanee Antony culminated in a delivery for Natan to power in off the head.
There were no further goals throughout the course of the second period, leaving the Blaugrana and Los Verdiblancos to settle for a point apiece.
Meanwhile, Real Madrid will count themselves lucky after suffering a 2-1 defeat to Valencia CF earlier in the day.
There was a new face in the goal for Madrid as Fran Gonzalez stepped up ahead of injured Andriy Lunin, as Thibaut Courtois was named on the bench.
A buoyant start was on the cards for Los Blancos after Kylian Mbappe went down in the box following a foul by Cesar Tarrega and won a penalty, but Vinicius Junior failed to capitalise.
Los Che made use of the reprieve and raced ahead two minutes later when Mouctar Diakhaby rose above Antonio Rudiger to head in a corner-kick.
Madrid battled to get an immediate response despite having the moments through amongst others Mbappe - thus saw the visiting outfit take the advantage to the halftime period.
However, Los Blancos did level the tie five minutes in the second period after Brazilian star Vinicius hooked a flick-on delivery from Jude Bellingham into the roof of the net.
The visitors secured victory in the dying stages when Rafa Mir charged down the right and cutback for Hugo Duro to head in and clinched all the points on offer.