Olympique Lyon crushed lower-tier side FBBP 7-0 in the French Cup last 32 at the Stade Marcel-Verchere on Saturday evening.
Moussa Dembele bagged a first-half brace while Martin Terrier, Maxwel Cornet, Bertrand Traore, Houssem Aouar and Anthony Racioppi added to the score-sheet in the second half.
RC Strasbourg thumped second-tier Le Portel 4-1 at the Stade de IEpopee
Goals came from Benjamin Corgnet after 10 minutes with a second half brace from Kevin Zohi followed by Adrien Lebean's penalty four minutes to the end.
The home side's consolation came ten minutes before the end of the first half through Gaetan Bultel as Strasbourg march into the next round.
Defending champions Rennes needed a dreaded penalty shoot-out to see off Amiens SC 5-4 on penalties after playing to a goalless draw over 120 minutes.
A tense shoot-out ended when Damien Da Silva netted the winning kick to guide his side into the next phase of the competition.
Nantes joined Stade Rennes and RC Strasbourg in the last 16 after a 2-0 victory over Bayonne at the Stade Jean-Dauger in Bayonne.
Kalifa Coulibaly netted the opener on 13 minutes before Mehdi Abeid completed the win in the final minute of the match.