Pochettino changed five from the loss to Monaco with Julian Draxler, Sebastian Kehrer, Abdou Diallo, Ivan Paredes and Idrissa Gueye coming in. Meanwhile, Dijon also made five changes.
PSG opened the scoring in the fifth minute when Diallo turned provider for Moise Kean who bamboozled the defender before slotting into the corner of the net.
The visitors won a penalty on the half-hour mark when Celina handballed from Rafinha's shot. Mbappe stepped up and made no mistake to double the lead.
Draxler thought he had scored in the 36th minute when he slotted home from an Ander Herrera throughball.
Six minutes after the interval, Mbappe grabbed his second. Rafinha slipped the ball through for the Frenchman and he hit it first-time past a helpless Racioppi.
Draxler had a goal narrowly ruled out for the second time in the match with 15 minutes to go.
In the 77th minute, Racioppi sloppily gave the ball away to the dangerous Sarabia, but the Dijon shot-stopper made up for his error to make the save.
It was 4-0 five minutes later when Danilo headed home from a Draxler delivery with Racioppi having come out and not got to the ball.
That would be the last meaningful action of the match as Pochettino's side bounced back from their defeat to rivals Monaco last weekend.