Goalkeeper Sergio Rico, Rafinha, Julian Draxler and Moise Kean were notable alterations from the UEFA Champions League defeat against Manchester United in midweek.
Kean, on-loan from Premier League side Everton, broke the deadlock on three minutes after charging at the front post to volley in a cross from Mitchel Bakker.
A second seemed a reality five minutes thereafter with Pablo Sarabia founding Neymar Junior who headed against the post before going on to fluff the follow-up.
PSG added a second in the midway stages as Kean rounded off his brace with an easy tap-in from good spate work by Neymar.
The Brazilians wizard stayed busy towards halftime when a cross from a short free-kick from the right found Danilo Pereira, who drew a thumping save off Saturnin Allagbe.
PSG made a positive start to the second half as a free-kick from Neymar found Sarabia, who had Allagbe to work with a cracking volley from the back-post.
A substitution from the visitors on 55 minutes had Pape Cheikh Diop coming in for Wesley Lautoa, while PSG dropped in Ander Herrera for Julian Draxler seconds later.
The Ligue 1 champions managed the closing quarter rather comfortably, with the away side posing little in the way of goal-mouth opportunities.
Kylian Mbappe entered from the bench inside the last 20 minutes with Kean denied a hat-trick as he made way for the 2018 FIFA World Cup winner.
Mbappe marked his arrival in style when he bagged the third after slicing a ball from Neymar through the legs of Allagbe.
The forward doubled his tally in the last two minutes with a simple tap-in from a cross-field ball from Sarabia, giving the hosts an emphatic triumph.