AS Roma 0-2 Atalanta
As Roma's two-match winning run in Serie A was brought to an end by Atalanta, who grabbed a 2-0 victory in Rome.
Duvan Zapata replaced Josip Illic after halftime and netted the opener with 19 minutes to go whilst Martin De Roon doubled Atalanta's tally in the final minute.
Inter Milan 1-0 Lazio
Inter Milan reclaimed top spot after recording a hard-fought 1-0 win over Lazio at the San Siro Stadium.
Danilo D'Ambrosio headed home the game's only effort in the 26th minute following a Cristian Biraghi-in for his debut- delivery.
Fiorentina 2-1 Sampdoria
Fiorentina got their first win of the season after edging ten-man Sampdoria 2-1 at the Stadio Artemio Franchi.
German Pezzella headed the hosts in front on 31 minutes with Federico Chiesa doubling their advantage after 56 minutes, whilst Federico Bonazzoli grabbed their consolation on 79 minutes.
Jeison Murillo was given his marching orders for a second bookable offence 12 minutes into the second stanza.
Napoli 0-1 Cagliari
Ten-man Napoli succumbed to a shock a 1-0 loss against Cagliari at the San Paolo Stadium in Naples, falling behind the early pace-setters.
Substitute Lucas Castro provided the telling strike three minutes to full-time, whist Napoli had Kalidou Koulibaly giving a straight red on 88 minutes.
Genoa 0-0 Bologna
Genoa's struggling start continued following a goalless draw against Bologna at the Stadio Luigi Ferrari.
SPAL 1-3 Lecce
Lecce registered their second win of the season after dumping SPAL 3-1 at the San Paolo Mazza in Ferrara.
Marco Mancosu's 11th minute penalty opened matters, but Federico Di Franceso levelled after six minutes before Marco Calderoni restored the visitors lead two minutes to halftime. Mancosu added his second with another spot kick after 73 minutes, taking Lecce off the bottom-three.
Parma 1-0 Sassuolo
Sassuolo were brought back down to earth by Parma, who scraped to a hard-fought 1-0 win at the death.
Mehdi Bourabia, who came off the bench, slotted into his own net with the last kick of the game.