The Argentine talisman suffered a knee injury in Barca’s 2-1 victory over Las Palmas on Saturday, and has subsequently been ruled out of action for up to two months.
Yet Enrique feels his squad has enough depth two survive without their key forward, despite admitting it is a big blow for his side.
"All my players give always their top so I can't ask them more due to Messi’s absence,” the Blaugrana coach said.
"Messi and Rafinha injuries are challenges for us.
"We will do what we have to do without Messi, a player like him is impossible to replace but we showed during the preseason we know how to play without him, we will introduce new players.
“We have already thought about changing our playing style without Messi because our main goal is to be on the top at the end of the season.”
The Argentine is set to miss a number of high-profile matches, including three Champions League group stage fixtures, two international games for his country and up to six La Liga fixtures, including the much-anticipated El Clasico against Real Madrid in mid-November.
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