The 23-year-old missed five months of last season with ankle ligament damage and is enduring another injury-ravaged campaign, having not played yet this term.
A metal plate needs to be inserted into Wilshere's leg to aid his full recovery.
“Due to a slow healing response from a fracture suffered in August, the club can confirm that Jack Wilshere is to undergo an operation to his left fibula,” an Arsenal statement read.
“The decision to intervene has been taken quickly after regular reviews by specialists, who feel that Jack's scans show that the healing process is not progressing as well as expected.
“Jack will have surgery in London in the forthcoming days. This will involve inserting a small plate in his left fibula. Jack is likely to be out for approximately three months. Everyone at the club wishes Jack well with his rehabilitation.”
Striker Danny Welbeck also set for an extended spell on the sidelines until at least the end of December following knee surgery.
Arsenal travel to Croatia for Wednesday's UEFA Champions League opener against Dinamo Zagreb on the back of a 2-0 victory over Stoke City in the Premier League.
