Wolverhampton Wanderers' impressive European journey came to an end after going down 1-0 to LaLiga side Sevilla in Duisburg.
Wolves could've gone ahead in the first 13 minutes; however Raul Jimenez had his penalty saved by Yassine Bounou after a foul on Adama Traore.
The Spaniards left it late as Lucas Ocampos netted the winner to confirm their semi-final date with Manchester United on Sunday evening.
Sevilla remain on course to win a record sixth Europa League title, while Wolves willl not be competing in Europe next season after finishing seventh in the Premier League.
Shakhtar Donetsk set up a UEFA Europa League semi-final date with Inter Milan after seeing off FC Basel 4-1 in the quarter-finals on Tuesday evening.
The Ukrainian side took the lead with just two minutes in through forward Junior Moraes and went to halftime with a second courtesy of Brazilian Taison.
A penalty in the last 15 minutes put Shakhtar in total ascendancy after Alan Patrick netted home, with Dodo putting the curtains on Basel, who got a consolation through Ricky van Wolfswinkel.