Spurs ran wholesale changes with Joe Hart, Harry Winks, Lucas Moura, Gareth Bale and Carlos Vinicius all getting starts after missing out against Arsenal.
Japhet Tanganga should've given Spurs the breakthrough six minutes in through a free-kick from Giovani Lo Celso, but Alireza Beiranvand palmed for a corner-kick.
Spurs still did all the probing minutes thereafter with Bale firing against a body of defenders in the area before Moura watched his first-time volley blocked away too.
Lo Celso aimed to take matters into his own hands after beating two challengers for a crack from the edge of the area, but found Beiranvand equal to the task.
The latter of which was at the fore front again to deny Vinicius from a one-on-one situation on the inside left of the six-yard area on the stroke of halftime.
Spurs wasted no time to blood fresh faces at halftime, with Steven Bergwijn introduced for Spanish international full-back Sergio Reguilon.
The Belgian side' resistance finally cracked on 57 minutes when a free-kick from Bale trickled off the post before landing at the feet of Vinicius, who tapped home easily.
Heung-Min Son gave the visitors a big fright at the midway point after bringing Beiranvand to a thumping save from an equally thumping attempt from the far post.
Spurs made the points safe on 70 minutes when unselfish play from Harry Kane released Lo Celso who applied a bottom-corner finish from the right-side of the area.
The LilyWhites enjoyed more openings following the closing minutes of the match, but weren't able to add to their tally as end the group stage phase top of Group J.