Bayer Leverkusen will meet Inter Milan in the Europa League quarter-finals following a 1-0 second-leg on Thursday night.
Moussa Diaby got the game's only goal in the second leg in the 51st minute to make it 4-1 on aggregate for Leverkusen.
Sevilla got the job done in the second leg to claim a 2-0 win over AS Roma at the Schauinsland-Reisen-Arena.
Reguilon opened the scoring in the 21st minute before Youssef En-Nesyri got the hosts' second on the stroke of halftime.
The record winners will lock horns with Wolverhampton Wanderers in the next round.
Wolverhampton Wanderers secured their ticket for the quarter-finals after defeating Olympiakos 1-0 in the second leg on Thursday night.
Raul Jimenez got the all-important strike in the second leg to secure a 1-0 win on the night and 2-1 aggregate victory.
FC Basel have set up a quarter-final clash with Shakhtar Donetsk after defeating Eintracht Frankfurt on Thursday night.
Fabian Frei struck in the 88th minute to secure a 1-0 win in the second leg, although the Swiss had already sealed after first-leg 3-0 win.