FC Barcelona gained passage to the last 16 of the UEFA Europa League after thumping Napoli 4-2 in the play-off round second-leg on Thursday.
Jordi Alba had Barca off the mark, but a penalty from Lorenzo Insigne got Napoli level before the Catalans raced into the lead at halftime through Frenkie de Jong and Gerard Pique.
Former Arsenal striker Pierre-Emerick Aubameyang bagged the visitors fourth in the second half before Matteo Politano handed Napoli a second as the tie concluded.
Borussia Dortmund were unable to stage a comeback in the playoff round as they went down 6-4 on aggregate to Glasgow Rangers despite drawing 2-2 on the night.
James Tavernier's early penalty had Rangers ahead before Jude Bellingham restored parity and left Donyell Malen to put Dortmund ahead at the interval only for Tavernier to level afterwards.
Real Betis managed to hold Russian powerhouse Zenit Saint Petersburg to a goalless draw to progress to the last 16.
The LaLiga side won the first-leg in Moscow last week, and thus advanced to the next phase of the tournament 3-2 on aggregate.
Serie A outfit Atalanta made it beyond the play-off round following a 3-0 second-leg victory over Olympiacos.
Atalanta increased their overall advantage from the first-leg courtesy of a first half strike from Joakim Maehle before Ruslan Malinovskyi hit a double after halftime.
There weren't such joy for fellow Italian outfit Lazio who bowed out of the tournament 4-3 on aggregate to FC Porto after playing to a 2-2 draw on the night.
An early opener from Ciro Immobile gave Lazio the ideal start only for Mehdi Taremi's penalty-kick and Mateus Uribe's finish took Porto ahead before Danilo Cataldi levelled at the death.
Bundesliga side RB Leipzig progressed beyond the playoff phase after a 3-1 second-leg victory over their LaLiga counterparts Real Sociedad.
Leipzig should've been on the front earlier on, but Andre Silva missed from the penalty spot though they still entered halftime ahead through Willi Orban.
Silva amended his earlier miss before Martin Zubimendi halved the advantage only for Emil Forsberg to hit the final nail in the coffin from the spot.
Despite suffering a 1-0 loss on the night, Sevilla still advanced to the last 16 following a 3-2 aggregate success over Dinamo Zagreb.
Mislav Orsic got the winner from the spot late in the second half, while Sevilla had Thomas Delaney dismissed in the dying minutes.