With the Covid-19 pandemic changing the format of the competition with only the top two divisions of South African football competing, the last-16 has arrived after just one round of fixtures.
Kaizer Chiefs and Baroka FC succumbed to second-tier sides Richards Bay United and Cape Town Spurs respectively and the GladAfrica Championship sides have now set up ties with domestic rivals.
Spurs kick-off the round in a Cape Town derby against Cape Town All Stars, travelling across the road from their Ikamva base to Parrow Park on Friday, 26 February.
Meanwhile, reigning champions Mamelodi Sundowns face Polokwane City at the Lucas Masterpieces Moripe Stadium on Saturday afternoon at 15h00.
2018 Champions - Free State Stars
2017 Champions - SuperSport United
2015 Champions - Mamelodi Sundowns
2016 Champions - SuperSport United
2014 Champions - Orlando Pirates
2013 Champions - Kaizer Chiefs
2012 Champions - SuperSport United
2011 Champions - Orlando Pirates
2019 Champions - TS Galaxy
2020 Champions - Mamelodi Sundowns
Friday 26 February:
- Cape Town All Stars vs Cape Town Spurs - 15h00
- Tshakhuma Tsha Madzivhandila vs Swallows FC - 18h00
Saturday 27 February:
- Mamelodi Sundowns vs Polokwane City - 15h00
- Black Leopards vs AmaZulu - 15h00
- Maritzburg United vs Orlando Pirates - 18h00
Sunday 28 February: