Anthony Martial and Jesse Lingaard netted the other goals for the Red Devils, who top the pool on goal-difference along with Dutch side Feyenoord.
Bafana Bafana international striker Dino Ndlovu played for Azerbaijan side Qarabag in their 2-0 victory over Greek outfit PAOK that keep them in contention for the knockout stages.
Ndlovu featured in a lone striker role and was replaced 15 minutes before the end.
Ajax Amsterdam, without outcast Thulani Serero grabbed a 2-2 draw at Spanish La Liga side Celta Vigo, while Inter Milan beat English premier League Southampton 1-0 thanks to a goal from midfielder Antonio Candreva.