Isco, 26, has yet to start a single LaLiga game since the appointment of current manager Santiago Solari, which dates back to October 2018 and mustered just four goals and one assist this season.
With the Spain international growing disillusioned by his lack of opportunities at Real, the Daily Mail has reported Liverpool and Manchester United are both considering launching bids.
However, Juventus have also shortlisted the Los Blancos man, whose contract expires in 2022, for their off-season wishlist, according to Tuttosport.
With former teammate Cristiano Ronaldo at the Serie A champions, the publication states the 34-year-old has recommended his signing along with Marcelo - but the lure of the Premier League could be too much for the former Malaga man to refuse.