Jazira, who debuted in the tournament, started South African international Serero in their attacking component.
The host exerted authority inside five minutes after a ball from Mohamed Jamal released Zayed Al Ameri , who went and applied a composed finish.
Pirae were still on the ropes following the 25th minute and conceded a second through a close-range header from Ahmed Al Hashmi from a ball into the channels.
With Serero going in the referee's book for a rough challenge, Al Ameri were denied a brace following an offside call on 37 minutes after he applied a stern finish from a smart delivery.
There were no stopping Jazira getting a third goal as Serbian-born Milos Kosanovic fired a free-kick from close-range into the bottom-corner three minutes later.
Serero's time on the field of play ended ahead of the start of the second half as Mamadou Coulibaly came on with Zayed Sultan and Abdullrahman Al Ameri the other changes.
Pirae got handed a route back minutes from the break after a stroke of good fortune witnessed Mohammed Rabii direct a delivery into his own net.
Although as Pirae hoped for a comeback, Jazira bagged a fourth within 63 minutes through a left-footed shot in the area from Abdoulaye Diaby following a cross by Joao Victor.
With time ticking away, the host pushed for a fifth goal through the self-same Diaby but he strayed wide as the four goals were enough to seal a spot in the second round.