Kylian Mbappe, who celebrated his birthday, started on the bench but Angel Di Maria and Moise Kean started while Neymar Junior was unavailable due to injury.
PSG received licence aplenty to go forward in the earlier exchanges, and almost hit the front through Di Maria but Lille managed to drop back in time to clear the danger.
The hosts managed to come together and charged at the reigning champions following the half-hour mark, but Presnel Kimpembe showed resolute defensive nous.
Kean almost gifted PSG the lead in the last four minutes of the first half with a back-heel attempt from close-range, but Mike Maignan showed up with smart reflexes to parry the strike.
The Everton loanee had another go at Maignan from a square ball moments inside the second half, but in the end fired well off target.
Following an uneventful first half, Lille looked to take the match by the scruff of the neck and made a double substitution in Jonathan David and Timothy Weah.
David almost made his presence felt a minute after entering with a looping shot from a good supply, but PSG goalkeeper Keylor Navas pulled off a succession of saves to deny the forward.
Lille continued charging at the visiting side in the closing minutes, whilst PSG unable to get out of first gear and into proper rhythm.
In the end, it finished goalless between Lille and PSG in Ligue 1 as the defending champions missed out on a chance to ascend to the top of the title.