Astana claimed a famous win over Manchester United in their final home Group L clash on Thursday evening.
The Red Devils, who clinched qualification on the last match day, went ahead through Jesse Lingard's deflected strike after just 10 minutes.
After a slow start, the hosts equalised on 55 minutes through Dimitry Shomko's neat finish, before the turnaround was complete through a Di'Shon Bernard own goal in the 62nd minute.
Getafe boosted their hopes of qualifying for the knockout stages with a 1-0 win away to Trabzonspor.
Jamie Mata's 50th minute strike was enough to seal three points for the LaLiga outfit.
The win moved Getafe up to second spot in Group C, level on points with third place Krasnodar.
FC Basel missed the chance to seal top spot in Group C following a 1-0 loss to away to Krasnodar.
The hosts secured the spoils thanks to Ari's 72nd minute to move Krasnodar up third ahead of their final group game against Getafe.
Basel, however, remain top of the group and will qualify if they defeat Trabzanspor in their final group.