The matches against the West Africans will take place on 16 and 19 February at Peter Mokaba Stadium.
Amajita will also travel to Ndola to play a friendly against Zambia on 8 February.
National U-20 coach Thabo Senong believes the team will benefit greatly from these fixtures.
“We are very happy to have secured these matches and I believe we will gain a lot of momentum with these friendly matches against Zambia and Mali. We have two West African teams in our group, so these matches will assist us in addressing some strengths and weakness of the West Africans.
“In the match against Zambia, we will be looking more at ourselves. We need the players to gain confidence in the box, we need our midfielders and defenders to play as a unit and we need to re-emphasise the levels of fitness,” said Senong.
Amajita will begin their first phase of preparations on Thursday before travelling to Zambia. The team will then break camp for a few days before regrouping for the second phase of preparations on 13 February where they will pitch tent in Limpopo and play the two matches against Mali.
The first match against the Eagles of Mali will be played behind closed doors and kicks off at 19h00, while the official international friendly will take place three days later. Kick-off is scheduled for 15h00 and entrance will be free.